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KMID : 1001020120100030130
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Korean Journal of Urological Oncology
2012 Volume.10 No. 3 p.130 ~ p.137
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RNASEL Gene Polymorphisms are Associated with PSA Level and Prostatic Volume in Korean Men with Benign Prostatic Hyperplasia
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Kim Hae-Jong
Lee Jae-Hyouk
Chang In-Ho
Kim Tae-Hyoung
Byun Seok-Soo
Myung Soon-Chul
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Abstract
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Purpose: The precise etiology of benign prostatic hyperplasia (BPH) is not fully determined, however, it is known that inflammatory processes have a role in the pathogenesis of BPH initiation and progression. RNASEL at chromosome 1q25 encodes ribonuclease L, part of the interferon-mediated immune response to viral infection. The aim of study was to investigate the relationship between RNASEL polymorphisms and BPH.
Materials and Methods: With a cohort of 173 BPH subjects, we genotyped ten single nucleotide polymorphisms (SNPs) in the RNASEL gene using Golden gate assay. The associations with PSA levels or prostatic volume among the BPH subjects were analyzed. Results: There were significant associations between three SNPs and low prostate-specific antigen groups (rs672527, rs10911099, rs12034888). One SNP (rs11072) was associated with prostatic volume. We detected a strong association in genotype frequencies of RNASEL SNP (rs672527) between subjects with high transitional volume.
Conclusions: The result suggests that RNASEL may be associated with PSA level and prostatic volume in BPH
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KEYWORD
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Prostatic hyperplasia, 2-5A-dependent ribonuclease, Polymorphism
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